VEGFR2 Polyclonal Antibody

Catalog No.: 

Product Name: VEGFR2 Polyclonal Antibody

Catalog No.: ALT5845

Reactivity: Human;Rat;Mouse

Applications: WB;IHC-p;IF(paraffin section);ELISA

Source: Polyclonal, Rabbit,IgG

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Dilution: Western Blot: 1/500 – 1/2000.IHC-p/f:1:50-300. ELISA 1:10000-20000

Storage Stability: -20°C/1 year

Gene Name: KDR FLK1 VEGFR2

Protein Name: VEGFR2

Human Gene ID: 3791

Human Swiss Prot No.: P35968

Other Name: Vascular endothelial growth factor receptor 2 (VEGFR-2;EC;Fetal liver kinase 1;FLK-1;Kinase insert domain receptor;KDR;Protein-tyrosine kinase receptor flk-1;CD antigen CD309)

Subcellular Location: Cell junction . Endoplasmic reticulum . Cell membrane . Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). .; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. EaYy endosome. Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus.; [Isoform 2]: Secreted .; [Isoform 3]: Secreted.

Expression: Detected in cornea (at protein level). Widely expressed.

Immunohistochemical analysis of paraffin-embedded human-breast-cancer, antibody was diluted at 1:200

Immunohistochemical analysis of paraffin-embedded human-placenta, antibody was diluted at 1:200

For research use only. Not for use in diagnostic procedures.

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