Product Name: SRBS2 rabbit pAb
Catalog No.: ALT7434
Reactivity: Human; Mouse;Rat
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution: WB 1：500-2000
Storage Stability: -20°C/1 year
Gene Name: SORBS2 ARGBP2 KIAA0777
Protein Name: SRBS2
Human Gene ID: 8470
Human Swiss Prot No.: O94875
Subcellular Location: Cytoplasm, perinuclear region . Apical cell membrane . Cell junction, focal adhesion . Cell projection, lamellipodium . Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells. .
Expression: Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells. In the pancreas, mainly expressed in acinar cells, duct cells and all cell types in islets (at protein level). Tends to be down-regulated in pancreatic adenocarcinomas ans metastases.
Western blot analysis of lysates from HuvEc cells, primary antibody was diluted at 1:1000, 4°over night
For research use only. Not for use in diagnostic procedures.