Product Name: OPTN rabbit pAb
Catalog No.: ALT8067
Reactivity: Human; Mouse;Rat
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, and 0.78% sodium azide.
Dilution: WB 1:500-2000
Storage Stability: -20°C/1 year
Gene Name: OPTN FIP2 GLC1E HIP7 HYPL NRP
Protein Name: OPTN
Human Gene ID: 10133
Human Swiss Prot No.: Q96CV9
Other Name: Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Subcellular Location: Cytoplasm, perinuclear region. Golgi apparatus . Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Found in the perinuclear region and associates with the Golgi apparatus (PubMed:27534431). Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy. .
Expression: Present in aqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.
For research use only. Not for use in diagnostic procedures.