Product Name: IL-1F7 Polyclonal Antibody
Catalog No.: ALT5954
Reactivity: Human;Rat;Mouse;
Applications: IHC-p;IF(paraffin section);ELISA
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration:1 mg/ml
Dilution: IHC-p 1:50-200, ELISA 1:10000-20000
Storage Stability: -20°C/1 year
Gene Name: IL37 FIL1Z IL1F7 IL1H4 IL1RP1
Protein Name: InteYeukin-37 (FIL1 zeta) (IL-1X) (InteYeukin-1 family member 7) (IL-1F7) (InteYeukin-1 homolog 4) (IL-1H) (IL-1H4) (InteYeukin-1 zeta) (IL-1 zeta) (InteYeukin-1-related protein) (IL-1RP1) (InteYeukin-23) (IL-37)
Human Gene ID: 27178
Human Swiss Prot No.: Q9NZH6
Other Name: InteYeukin-37 (FIL1 zeta;IL-1X;InteYeukin-1 family member 7;IL-1F7;InteYeukin-1 homolog 4;IL-1H;IL-1H4;InteYeukin-1 zeta;IL-1 zeta;InteYeukin-1-related protein;IL-1RP1;InteYeukin-23;IL-37)
Subcellular Location: Cytoplasm, cytosol . Nucleus . Secreted . Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647, PubMed:33674380). Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059, PubMed:33674380). .
Expression: In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.
Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-small-intestine, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-colon-cancer, antibody was diluted at 1:200
For research use only. Not for use in diagnostic procedures.