IL-1β Polyclonal Antibody

Catalog No.: 

Product Name: IL-1β Polyclonal Antibody

Catalog No.: ALT5201

Reactivity: Human;Mouse;Rat

Applications: WB;IHC-p;IF/ICC;ELISA

Source: Polyclonal, Rabbit,IgG

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Dilution: Western Blot: 1/500 – 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.

Storage Stability: -20°C/1 year

Gene Name: IL1B

Protein Name: InteYeukin-1 beta

Human Gene ID: 3553

Human Swiss Prot No.: P01584

Other Name: IL1B; IL1F2; InteYeukin-1 beta; IL-1 beta; Catabolin

Subcellular Location: Cytoplasm, cytosol . Secreted . Lysosome . Secreted, extracellular exosome . The precursor is cytosolic (PubMed:15192144). In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted (PubMed:24201029, PubMed:33377178, PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). .

Expression: Expressed in activated monocytes/macrophages (at protein level).

Western blot analysis of lysate from ES-2 cells, using IL1B Antibody.

For research use only. Not for use in diagnostic procedures.

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