Product Name: Granulins rabbit pAb
Catalog No.: ALT7987
Reactivity: Human;Rat;Mouse;
Applications: WB; ELISA
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration:1 mg/ml
Dilution: WB 1:1000-2000 ELISA 1:5000-20000
Storage Stability: -20°C/1 year
Gene Name: GRN
Protein Name: Granulins
Human Gene ID: 2896
Human Swiss Prot No.: P28799
Other Name: Granulins (Proepithelin;PEPI) [Cleaved into: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]
Subcellular Location: Secreted . Lysosome . Endocytosed by SORT1 and delivred to lysosomes (PubMed:21092856, PubMed:28073925). Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (PubMed:26370502, PubMed:28073925). Co-localized with GBA in the intracellular trafficking compartments until to lysosome (By similarity). .
Expression: In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
For research use only. Not for use in diagnostic procedures.