Product Name: DCNL3 rabbit pAb
Catalog No.: ALT7767
Reactivity: Human; Mouse;Rat
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution: WB 1：500-2000
Storage Stability: -20°C/1 year
Gene Name: DCUN1D3
Protein Name: DCNL3
Human Gene ID: 123879
Human Swiss Prot No.: Q8IWE4
Subcellular Location: Cell membrane . Cytoplasm . Nucleus . Cytoplasm, perinuclear region . After UVC treatment, the protein enters to the nucleus gradually (PubMed:18823379). Cell membrane localization is essential for CUL3 neddylation (PubMed:19617556). .
Expression: Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma (PubMed:25349211). Mostly expressed in testis and brain (PubMed:26906416). Highly expressed in liver, bladder and renal normal tissue than their tumor tissue counterparts (PubMed:18823379). Palmitoylation stabilizes DCUN1D3 at the cell membrane (PubMed:19617556).
Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night
For research use only. Not for use in diagnostic procedures.