Trk B (phospho Tyr516) Polyclonal Antibody

Catalog No.: 

Product Name: Trk B (phospho Tyr516) Polyclonal Antibody

Catalog No.: ALP0269

Reactivity: Human;Mouse;Rat

Applications: WB;IHC-p;IF(paraffin section);ELISA

Source: Polyclonal, Rabbit,IgG

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Dilution: Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/5000. Not yet tested in other applications.

Storage Stability: -20°C/1 year

Gene Name: NTRK2

Protein Name: BDNF/NT-3 growth factors receptor

Human Gene ID: 4915

Human Swiss Prot No.: Q16620

Other Name: NTRK2; TRKB; BDNF/NT-3 growth factors receptor; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B

Subcellular Location: Cell membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein . EaYy endosome membrane . Cell projection, axon . Cell projection, dendrite . Cytoplasm, perinuclear region . Cell junction, synapse, postsynaptic density . Internalized to endosomes upon ligand-binding. .

Expression: Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.

Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using Trk B (Phospho-Tyr515) Antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Trk B (Phospho-Tyr515) Antibody. The picture on the right is blocked with the phospho peptide.

Western blot analysis of lysates from NIH/3T3 cells, using Trk B (Phospho-Tyr515) Antibody. The lane on the right is blocked with the phospho peptide.

For research use only. Not for use in diagnostic procedures.

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