Product Name: TOPBP1 rabbit pAb
Catalog No.: ALT8022
Reactivity: Human; Mouse;Rat
Applications: WB
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, and 0.33% sodium azide.
Concentration:1 mg/ml
Dilution: WB 1:500-2000
Storage Stability: -20°C/1 year
Gene Name: TOPBP1 KIAA0259
Protein Name: TOPBP1
Human Gene ID: 11073
Human Swiss Prot No.: Q92547
Other Name: DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)
Subcellular Location: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX- independent manner. .
Expression: Highly expressed in heart, brain, placenta, lung and kidney.
For research use only. Not for use in diagnostic procedures.