Stat3 (phospho Tyr705) Polyclonal Antibody

Catalog No.: 

Product Name: Stat3 (phospho Tyr705) Polyclonal Antibody

Catalog No.: ALP0251

Reactivity: Human;Mouse;Rat;Pig(Test by out customer)

Applications: IF/ICC;WB;IHC-p;IP;ELISA

Source: Polyclonal, Rabbit,IgG

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Dilution: IF: 1:50-200 Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. Immunoprecipitation: 2-5 ug/mg lysate. ELISA: 1/20000. Not yet tested in other applications.

Storage Stability: -20°C/1 year

Gene Name: STAT3

Protein Name: Signal transducer and activator of transcription 3

Human Gene ID: 6774

Human Swiss Prot No.: P40763

Other Name: STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor

Subcellular Location: Cytoplasm . Nucleus . Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and AY2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.

Expression: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in naive CD4(+) T cells as well as T-helper Th17, Th1 and Th2 cells (PubMed:31899195).

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using STAT3 (Phospho-Tyr705) Antibody. The picture on the right is blocked with the phospho peptide.

Western blot analysis of lysates from HeLa cells, using STAT3 (Phospho-Tyr705) Antibody. The lane on the right is blocked with the phospho peptide.

For research use only. Not for use in diagnostic procedures.

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