Raf-1 (phospho Ser642) Polyclonal Antibody

Catalog No.: 

Product Name: Raf-1 (phospho Ser642) Polyclonal Antibody

Catalog No.: ALP0499

Reactivity: Human;Mouse;Rat

Applications: WB;ELISA;IHC-p

Source: Polyclonal, Rabbit,IgG

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Dilution: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

Storage Stability: -20°C/1 year

Gene Name: RAF1

Protein Name: RAF proto-oncogene serine/threonine-protein kinase

Human Gene ID: 5894

Human Swiss Prot No.: P04049

Other Name: RAF1; RAF; RAF proto-oncogene serine/threonine-protein kinase; Proto-oncogene c-RAF; cRaf; Raf-1

Subcellular Location: Cytoplasm. Cell membrane. Mitochondrion. Nucleus. Colocalizes with RGS14 and BRAF in both the cytoplasm and membranes. Phosphorylation at Ser-259 impairs its membrane accumulation. Recruited to the cell membrane by the active Ras protein. Phosphorylation at Ser-338 and Ser-339 by PAK1 is required for its mitochondrial localization. Retinoic acid-induced Ser-621 phosphorylated form of RAF1 is predominantly localized at the nucleus.

Expression: In skeletal muscle, isoform 1 is more abundant than isoform 2.

Western blot analysis of C-RAF (Phospho-Ser642) Antibody. The lane on the right is blocked with the C-RAF (Phospho-Ser642) peptide.

For research use only. Not for use in diagnostic procedures.

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