PR (phospho Ser190) Polyclonal Antibody

Catalog No.: 

Product Name: PR (phospho Ser190) Polyclonal Antibody

Catalog No.: ALP0235

Reactivity: Human;Monkey

Applications: WB;IHC-p;IF(paraffin section);ELISA

Source: Polyclonal, Rabbit,IgG

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Dilution: Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/20000. Not yet tested in other applications.

Storage Stability: -20°C/1 year

Gene Name: PGR

Protein Name: Progesterone receptor

Human Gene ID: 5241

Human Swiss Prot No.: P06401

Other Name: PGR; NR3C3; Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3

Subcellular Location: Nucleus. Cytoplasm. Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.; [Isoform A]: Nucleus. Cytoplasm. Mainly nuclear.; [Isoform 4]: Mitochondrion outer membrane .

Expression: In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region-specific responses to hormonal stimuli.

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Progesterone Receptor (Phospho-Ser190) Antibody.

Western blot analysis of lysates from COS7 cells treated with EGF, using Progesterone Receptor (Phospho-Ser190) Antibody. The lane on the right is blocked with the phospho peptide.

For research use only. Not for use in diagnostic procedures.

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