Product Name: FGFR-3 Polyclonal Antibody
Catalog No.: ALT1701
Reactivity: Human;Mouse;Rat
Applications: WB;IHC-p;IF(paraffin section);ELISA
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration:1 mg/ml
Dilution: Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/10000. Not yet tested in other applications.
Storage Stability: -20°C/1 year
Gene Name: FGFR3
Protein Name: Fibroblast growth factor receptor 3
Human Gene ID: 2261
Human Swiss Prot No.: P22607
Other Name: FGFR3; JTK4; Fibroblast growth factor receptor 3; FGFR-3; CD antigen CD333
Subcellular Location: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Endoplasmic reticulum. The activated receptor is rapidly internalized and degraded. Detected in intracellular vesicles after internalization of the autophosphorylated receptor.; [Isoform 2]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane ; Single-pass type I membrane protein .
Expression: Expressed in brain, kidney and testis. Very low or no expression in spleen, heart, and muscle. In 20- to 22-week old fetuses it is expressed at high level in kidney, lung, small intestine and brain, and to a lower degree in spleen, liver, and muscle. Isoform 2 is detected in epithelial cells. Isoform 1 is not detected in epithelial cells. Isoform 1 and isoform 2 are detected in fibroblastic cells.
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using FGFR3 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from LOVO cells, using FGFR3 Antibody. The lane on the right is blocked with the synthesized peptide.
For research use only. Not for use in diagnostic procedures.