Product Name: Caspase-8 Polyclonal Antibody
Catalog No.: ALT6191
Reactivity: Human; Mouse; Rat
Applications: IHC-p;IF(paraffin section);WB
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration:1 mg/ml
Dilution: IHC-p 1:50-200, WB 1:500-2000
Storage Stability: -20°C/1 year
Gene Name: CASP8 MCH5
Protein Name: Caspase8
Human Gene ID: 841
Human Swiss Prot No.: Q14790
Other Name: Caspase-8 (CASP-8;EC 3.4.22.61;Apoptotic cysteine protease;Apoptotic protease Mch-5;CAP4;FADD-homologous ICE/ced-3-like protease;FADD-like ICE;FLICE;ICE-like apoptotic protease 5;MORT1-associated ced-3 homolog;MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
Subcellular Location: Cytoplasm . Nucleus .
Expression: Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.
57 Yang B, Wang L, Luo X, et al. SPAG6 silencing inhibits the growth of the malignant myeloid cell lines SKM-1 and K562 via activating p53 and caspase activation-dependent apoptosis[J]. International journal of oncology, 2015, 46(2): 649-656.
536 Tan X, Jin P, Feng L, et al. Protective effect of luteolin on cigarette smoke extract‑induced cellular toxicity and apoptosis in normal human bronchial epithelial cells via the Nrf2 pathway[J]. Oncology reports, 2014, 31(4): 1855-1862.
801 Li P, He Q Y, Luo C Q. Overexpression of miR‐200b inhibits the cell proliferation and promotes apoptosis of human hypertrophic scar fibroblasts in vitro[J]. The Journal of dermatology, 2014, 41(10): 903-911.
860 Yu Y, Yang Y, Wang J. Anti-apoptotic and apoptotic pathway analysis of arsenic trioxide‑induced apoptosis in human gastric cancer SGC-7901 cells[J]. Oncology reports, 2014, 32(3): 973-978.
Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
For research use only. Not for use in diagnostic procedures.