Product Name: CASC3 rabbit pAb
Catalog No.: ALT6721
Reactivity: Human; Mouse;Rat
Applications: WB
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration:1 mg/ml
Dilution: WB 1:500-2000
Storage Stability: -20°C/1 year
Gene Name: CASC3 MLN51
Protein Name: CASC3
Human Gene ID: 22794
Human Swiss Prot No.: O15234
Other Name:
Subcellular Location: Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Nucleus speckle . Cytoplasm, Stress granule . Cytoplasm, Cytoplasmic ribonucleoprotein granule . Cell projection, dendrite . Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA (PubMed:15166247). In nuclear speckles, colocalizes with MAGOH. Under stress conditions, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules (PubMed:17652158). In the dendrites of hippocampal neurons, localizes to dendritic ribonucleoprotein granules (By similarity). .
Expression: Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers.
Western blot analysis of lysates from KB cells, primary antibody was diluted at 1:1000, 4°over night
For research use only. Not for use in diagnostic procedures.