Product Name: Bamacan (Phospho-Ser1083) Polyclonal Antibody
Catalog No.: ALP1228
Reactivity: Human; Mouse; Rat
Applications: IHC-p;IF(paraffin section);WB
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration:1 mg/ml
Dilution: IHC-p 1:50-200, WB 1:500-2000
Storage Stability: -20°C/1 year
Gene Name: SMC3 BAM BMH CSPG6 SMC3L1
Protein Name: Bamacan (Phospho-Ser1083)
Human Gene ID: 9126
Human Swiss Prot No.: Q9UQE7
Other Name: Structural maintenance of chromosomes protein 3 (SMC protein 3;SMC-3;Basement membrane-associated chondroitin proteoglycan;Bamacan;Chondroitin sulfate proteoglycan 6;Chromosome-associated polypeptide;hCAP)
Subcellular Location: Nucleus . Chromosome . Chromosome, centromere . Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser-1083 is preferentially associated with unsynapsed chromosomal regions (By similarity). .
Expression: B-cell,Epithelium,Eye,Neuron,Umbilical cord blood,
Immunohistochemical analysis of paraffin-embedded human brain tumor. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
For research use only. Not for use in diagnostic procedures.