Product Name: ATF-2 (phospho-Thr69/71) rabbit pAb
Catalog No.: ALP1266
Reactivity: Human;Mouse;Rat
Applications: WB
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration:1 mg/ml
Dilution: WB 1:1000-2000
Storage Stability: -20°C/1 year
Gene Name: ATF2 CREB2 CREBP1
Protein Name: ATF-2 (Thr69/71)
Human Gene ID: 1386
Human Swiss Prot No.: P15336
Other Name: Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)
Subcellular Location: Nucleus. Cytoplasm. Mitochondrion outer membrane. Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF).
Expression: Ubiquitously expressed, with more abundant expression in the brain.
For research use only. Not for use in diagnostic procedures.