Product Name: AS160 (phospho-Ser588) rabbit pAb
Catalog No.: ALP1264
Reactivity: Human;Mouse
Applications: WB
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration:1 mg/ml
Dilution: WB 1:1000-2000
Storage Stability: -20°C/1 year
Gene Name: TBC1D4 AS160 KIAA0603
Protein Name: AS160 (Ser588)
Human Gene ID: 9882
Human Swiss Prot No.: O60343
Other Name: TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160)
Subcellular Location: Cytoplasm . Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.
Expression: Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis.
For research use only. Not for use in diagnostic procedures.