Product Name: ABCB5 rabbit pAb
Catalog No.: ALT7794
Applications: WB; ELISA
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution: WB 1:1000-2000 ELISA 1:5000-20000
Storage Stability: -20°C/1 year
Gene Name: ABCB5
Protein Name: ABCB5
Human Gene ID: 340273
Human Swiss Prot No.: Q2M3G0
Other Name: ATP-binding cassette sub-family B member 5 (ABCB5 P-gp;P-glycoprotein ABCB5)
Subcellular Location: Cell membrane ; Multi-pass membrane protein .
Expression: Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expression in normal skin. In melanoma, marks malignant melanoma-initiating cells (MMIC), in which clinical virulence resides as a consequence of unlimited self-renewal capacity, resulting in inexorable tumor progression and metastasis. Also highly expressed in a number of leukemia cells. Expressed in basal limbal epithelium.
For research use only. Not for use in diagnostic procedures.