Product Name: 53BP1 (phospho-Ser1618) rabbit pAb
Catalog No.: ALP1253
Reactivity: Human;Rat
Applications: WB
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration:1 mg/ml
Dilution: WB 1:1000-2000
Storage Stability: -20°C/1 year
Gene Name: TP53BP1
Protein Name: 53BP1 (Ser1618)
Human Gene ID: 7158
Human Swiss Prot No.: Q12888
Other Name: Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)
Subcellular Location: Nucleus . Chromosome . Chromosome, centromere, kinetochore . Localizes to the nucleus in absence of DNA damage (PubMed:28241136). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at ‘Lys-15’ (H2AK15Ub) and histone H4 dimethylated at ‘Lys-20’ (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600). Associated with kinetochores during mitosis (By similarity). .
Expression: Cerebellum,Cervix,Epithelium,Myeloid leukemia cell,Skeletal muscle,
For research use only. Not for use in diagnostic procedures.