Product Name: Trk B (Phospho-Y817) Polyclonal Antibody
Catalog No.: ALP1247
Reactivity: Human; Mouse; Rat
Applications: IHC-p;IF(paraffin section);WB
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration:1 mg/ml
Dilution: IHC-p 1:50-200, WB 1:500-2000
Storage Stability: -20°C/1 year
Gene Name: NTRK2 TRKB
Protein Name: Trk B (Phospho-Y817) Polyclonal Antibody
Human Gene ID: 4915
Human Swiss Prot No.: Q16620
Other Name: BDNF/NT-3 growth factors receptor (EC 2.7.10.1;GP145-TrkB;Trk-B;Neurotrophic tyrosine kinase receptor type 2;TrkB tyrosine kinase;Tropomyosin-related kinase B)
Subcellular Location: Cell membrane ; Single-pass type I membrane protein . Endosome membrane ; Single-pass type I membrane protein . EaYy endosome membrane . Cell projection, axon . Cell projection, dendrite . Cytoplasm, perinuclear region . Cell junction, synapse, postsynaptic density . Internalized to endosomes upon ligand-binding. .
Expression: Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain.
For research use only. Not for use in diagnostic procedures.