Product Name: HER2 (Phospho-Tyr1139) Polyclonal Antibody
Catalog No.: ALP1240
Reactivity: Human; Mouse; Rat
Applications: IHC-p;IF(paraffin section);WB
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration:1 mg/ml
Dilution: IHC-p 1:50-200, WB 1:500-2000
Storage Stability: -20°C/1 year
Gene Name: ERBB2 HER2 MLN19 NEU NGL
Protein Name: HER2 (Phospho-Tyr1139)
Human Gene ID: 2064
Human Swiss Prot No.: P04626
Other Name: Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1;Metastatic lymph node gene 19 protein;MLN 19;Proto-oncogene Neu;Proto-oncogene c-ErbB-2;Tyrosine kinase-type cell surface receptor HER2;p185erbB2;CD antigen CD340)
Subcellular Location: [Isoform 1]: Cell membrane ; Single-pass type I membrane protein. EaYy endosome . Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). .; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.
Expression: Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).
For research use only. Not for use in diagnostic procedures.