Product Name: Abl1/2 (phospho Tyr393/439) Polyclonal Antibody
Catalog No.: ALP0619
Reactivity: Human;Mouse;Monkey
Applications: WB;IHC-p;IF(paraffin section);ELISA
Source: Polyclonal, Rabbit,IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration:1 mg/ml
Dilution: Western Blot: 1/500 – 1/2000. Immunohistochemistry: 1/100 – 1/300. ELISA: 1/10000. Not yet tested in other applications.
Storage Stability: -20°C/1 year
Gene Name: ABL1/ABL2
Protein Name: Tyrosine-protein kinase ABL1/2
Human Gene ID: 25/27
Human Swiss Prot No.: P00519/P42684
Other Name: ABL1; ABL; JTK7; Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150; ABL2; ABLL; ARG; Abelson tyrosine-protein kinase 2; Abelson murine leukemia vira
Subcellular Location: Cytoplasm, cytoskeleton. Nucleus. Mitochondrion . Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity). .; [Isoform IB]: Nucleus membrane; Lipid-anchor. The myristoylated c-ABL protein is reported to be nuclear.
Expression: Widely expressed.
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using Abl (Phospho-Tyr412) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of lysates from COS7 cells treated with Adriamycin 0.5ug/ml 24h, using Abl (Phospho-Tyr412) Antibody. The lane on the right is blocked with the phospho peptide.
For research use only. Not for use in diagnostic procedures.